Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations

Rebecca K. Golden, Loretta T. Sutkus, Laura L. Bauer, Sharon M. Donovan, Ryan N. Dilger

Research output: Contribution to journalArticlepeer-review

Abstract

Sialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-SL), comprise a large portion of human milk and have been known to support development over the first year of life. While research has investigated the impact of early-life supplementation, longer-term supplementation remains relatively unexplored. Consequently, the following study assesses the impact of supplementation of either 3ˊ-SL or 6ˊ-SL on growth performance, tolerance, and brain sialic acid concentrations. Two-day-old piglets (n = 75) were randomly assigned to a commercial milk replacer ad libitum without or with 3ˊ-SL or 6ˊ-SL (added at 0.2673% on an as-is basis). Daily body weight and feed disappearance were recorded to assess growth performance and tolerance. Pigs were euthanized for sample collection on postnatal day 33 (n = 30) or 61 (n = 33), respectively. Across growth performance, clinical chemistry and hematology, histomorphology, and sialic acid quantification, dietary differences were largely unremarkable at either time-point. Overall, SA was well-tolerated both short-term and long-term.

Original languageEnglish (US)
Article number1278804
JournalFrontiers in Nutrition
Volume10
DOIs
StatePublished - 2023

Keywords

  • 3ˊ-sialyllactose
  • 6ˊ-sialyllactose
  • growth
  • hematology
  • histomorphology
  • sialic acid

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

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