TY - JOUR
T1 - Determinants of fluid intelligence in healthy aging
T2 - Omega-3 polyunsaturated fatty acid status and frontoparietal cortex structure
AU - Zamroziewicz, Marta K.
AU - Paul, Erick J.
AU - Zwilling, Chris E.
AU - Barbey, Aron Keith
N1 - Funding Information:
the Center for Nutrition, Learning, and Memory (funded by Abbott Nutrition) during the conduct of the study.
Funding Information:
Funding This work was supported by a grant from Abbott Nutrition through the Center for Nutrition, Learning, and Memory at the University of Illinois (ANGC1205; PI: Barbey).
Funding Information:
Authors are grateful to Tapas Das and Suzette Pereira for their feedback in the drafting of this manuscript. We are also grateful to Joachim Operskalski, Kelsey Campbell, Michael Kruepke, Jack Kuhns, and Nikolai Sherepa for their invaluable help with the testing of participants and organization of this study.
PY - 2018/9/14
Y1 - 2018/9/14
N2 - Introduction: Accumulating evidence indicates that cognitive decline depends not only upon changes in brain health, but critically, also upon nutritional status. Decline in fluid intelligence, one of the most debilitating aspects of cognitive aging, has been linked to omega-3 polyunsaturated fatty acid (PUFA) status; however, it is not known whether this phenomenon results from specific omega-3 PUFAs acting on particular aspects of brain health. Therefore, this study aims to explore whether particular patterns of omega-3 PUFAs influence fluid intelligence by supporting specific neural structures. Methods: We measured six plasma phospholipid omega-3 PUFAs, fluid intelligence, and regional gray matter volume in the frontal and parietal cortices in 100 cognitively intact older adults (65–75 years old). A four-step mediation analysis was implemented using principal component analysis and multivariate linear regressions, adjusted for age, gender, education, and body mass index. Results: The mediation analysis revealed that one pattern of omega-3 PUFAs, consisting of alpha-linolenic acid, stearidonic acid, and eicosatrienoic acid, was linked to fluid intelligence, and that total gray matter volume of the left frontoparietal cortex (FPC) fully mediated the relationship between this omega-3 PUFA pattern and fluid intelligence. Discussion: These data demonstrate that fluid intelligence may be optimally supported by specific omega-3 PUFAs through preservation of FPC gray matter structure in cognitively intact older adults. This report provides novel evidence for the benefits of particular omega-3 PUFA patterns on fluid intelligence and underlying gray matter structure.
AB - Introduction: Accumulating evidence indicates that cognitive decline depends not only upon changes in brain health, but critically, also upon nutritional status. Decline in fluid intelligence, one of the most debilitating aspects of cognitive aging, has been linked to omega-3 polyunsaturated fatty acid (PUFA) status; however, it is not known whether this phenomenon results from specific omega-3 PUFAs acting on particular aspects of brain health. Therefore, this study aims to explore whether particular patterns of omega-3 PUFAs influence fluid intelligence by supporting specific neural structures. Methods: We measured six plasma phospholipid omega-3 PUFAs, fluid intelligence, and regional gray matter volume in the frontal and parietal cortices in 100 cognitively intact older adults (65–75 years old). A four-step mediation analysis was implemented using principal component analysis and multivariate linear regressions, adjusted for age, gender, education, and body mass index. Results: The mediation analysis revealed that one pattern of omega-3 PUFAs, consisting of alpha-linolenic acid, stearidonic acid, and eicosatrienoic acid, was linked to fluid intelligence, and that total gray matter volume of the left frontoparietal cortex (FPC) fully mediated the relationship between this omega-3 PUFA pattern and fluid intelligence. Discussion: These data demonstrate that fluid intelligence may be optimally supported by specific omega-3 PUFAs through preservation of FPC gray matter structure in cognitively intact older adults. This report provides novel evidence for the benefits of particular omega-3 PUFA patterns on fluid intelligence and underlying gray matter structure.
KW - Brain aging
KW - Cognitive aging
KW - Cognitive performance
KW - Cortical integrity
KW - Nutrient biomarker patterns
KW - Nutrient biomarkers
KW - Nutritional cognitive neuroscience
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U2 - 10.1080/1028415X.2017.1324357
DO - 10.1080/1028415X.2017.1324357
M3 - Article
C2 - 28492102
SN - 1028-415X
VL - 21
SP - 570
EP - 579
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 8
ER -