Detection of two porcine circovirus type 2 genotypic groups in United States swine herds

Andrew K. Cheung, K. M. Lager, O. I. Kohutyuk, A. L. Vincent, S. C. Henry, R. B. Baker, R. R. Rowland, A. G. Dunham

Research output: Contribution to journalArticlepeer-review


In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.

Original languageEnglish (US)
Pages (from-to)1035-1044
Number of pages10
JournalArchives of Virology
Issue number5
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Virology


Dive into the research topics of 'Detection of two porcine circovirus type 2 genotypic groups in United States swine herds'. Together they form a unique fingerprint.

Cite this