Detection of DNA sequences using an alternating electric field in a nanopore capacitor

Grigori Sigalov, Jeffrey Comer, Gregory Timp, Aleksei Aksimentiev

Research output: Contribution to journalArticlepeer-review

Abstract

Molecular dynamics simulations revealed that back-and-forth motion of DNA strands through a 1 nm diameter pore exhibits sequence-specific hysteresis that arises from the reorientation of the DNA bases in the nanopore constriction. Such hysteresis of the DNA motion results in detectable changes of the electrostatic potential at the electrodes of the nanopore capacitor and in a sequence-specific drift of the DNA strand under an oscillating transmembrane bias. A strategy is suggested for sequencing DNA in a nanopore using the electric field that alternates periodically in time.

Original languageEnglish (US)
Pages (from-to)56-63
Number of pages8
JournalNano letters
Volume8
Issue number1
DOIs
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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