Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing

Miguel Ángel Aguirre, Kenneth D. Long, Nantao Li, Sello Lebohang Manoto, Brian T. Cunningham

Research output: Contribution to journalReview article

Abstract

The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.

Original languageEnglish (US)
Article number13
JournalChemosensors
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2018

Fingerprint

Optical resonators
optical resonators
counting
Nanoparticles
nanoparticles
attachment
interactions
Biocompatible Materials
Biomolecules
viruses
Viruses
detachment
Nanostructured materials
Liposomes
Electromagnetic fields
enzymes
Nanostructures
electromagnetic fields
Permittivity
Metals

Keywords

  • Biosensors
  • Nanoparticles
  • Photonic crystal cavities
  • Reflection interference
  • Whispering gallery mode

ASJC Scopus subject areas

  • Analytical Chemistry
  • Physical and Theoretical Chemistry

Cite this

Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing. / Aguirre, Miguel Ángel; Long, Kenneth D.; Li, Nantao; Manoto, Sello Lebohang; Cunningham, Brian T.

In: Chemosensors, Vol. 6, No. 2, 13, 01.06.2018.

Research output: Contribution to journalReview article

Aguirre, Miguel Ángel ; Long, Kenneth D. ; Li, Nantao ; Manoto, Sello Lebohang ; Cunningham, Brian T. / Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing. In: Chemosensors. 2018 ; Vol. 6, No. 2.
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