Abstract
The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.
| Original language | English (US) |
|---|---|
| Article number | 13 |
| Journal | Chemosensors |
| Volume | 6 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2018 |
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Keywords
- Biosensors
- Nanoparticles
- Photonic crystal cavities
- Reflection interference
- Whispering gallery mode
ASJC Scopus subject areas
- Analytical Chemistry
- Physical and Theoretical Chemistry
Cite this
Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing. / Aguirre, Miguel Ángel; Long, Kenneth D.; Li, Nantao; Manoto, Sello Lebohang; Cunningham, Brian T.
In: Chemosensors, Vol. 6, No. 2, 13, 01.06.2018.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Detection and digital resolution counting of nanoparticles with optical resonators and applications in biosensing
AU - Aguirre, Miguel Ángel
AU - Long, Kenneth D.
AU - Li, Nantao
AU - Manoto, Sello Lebohang
AU - Cunningham, Brian T.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.
AB - The interaction between nanoparticles and the electromagnetic fields associated with optical nanostructures enables sensing with single-nanoparticle limits of detection and digital resolution counting of captured nanoparticles through their intrinsic dielectric permittivity, absorption, and scattering. This paper will review the fundamental sensing methods, device structures, and detection instruments that have demonstrated the capability to observe the binding and interaction of nanoparticles at the single-unit level, where the nanoparticles are comprised of biomaterial (in the case of a virus or liposome), metal (plasmonic and magnetic nanomaterials), or inorganic dielectric material (such as TiO 2 or SiN). We classify sensing approaches based upon their ability to observe single-nanoparticle attachment/detachment events that occur in a specific location, versus approaches that are capable of generating images of nanoparticle attachment on a nanostructured surface. We describe applications that include study of biomolecular interactions, viral load monitoring, and enzyme-free detection of biomolecules in a test sample in the context of in vitro diagnostics.
KW - Biosensors
KW - Nanoparticles
KW - Photonic crystal cavities
KW - Reflection interference
KW - Whispering gallery mode
UR - http://www.scopus.com/inward/record.url?scp=85047633550&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047633550&partnerID=8YFLogxK
U2 - 10.3390/chemosensors6020013
DO - 10.3390/chemosensors6020013
M3 - Review article
AN - SCOPUS:85047633550
VL - 6
JO - Chemosensors
JF - Chemosensors
SN - 2227-9040
IS - 2
M1 - 13
ER -