Abstract
A synthetic methodology for developing a polymeric nanoparticle for targeted computed tomographic (CT) imaging is revealed in this manuscript. The work describes a new class of soft type, vascularly constrained, stable colloidal radio-opaque metal-entrapped polymeric nanoparticle using organically soluble radio-opaque elements encapsulated by synthetic amphiphile. This agent offers several-fold CT signal enhancement in vitro and in vivo demonstrating detection sensitivity reaching to the low nanomolar particulate concentration range.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 15522-15527 |
| Number of pages | 6 |
| Journal | Journal of the American Chemical Society |
| Volume | 131 |
| Issue number | 42 |
| DOIs | |
| State | Published - Oct 28 2009 |
| Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- General Chemistry
- Biochemistry
- Colloid and Surface Chemistry