TY - GEN
T1 - Designing compressive sensing DNA microarrays
AU - Sheikh, Mona A.
AU - Milenkovic, Olgica
AU - Baraniuk, Richard G.
PY - 2007
Y1 - 2007
N2 - A Compressive Sensing Microarray (CSM) is a new device for DNA-based identification of target organisms that lever-ages the nascent theory of Compressive Sensing (CS). In contrast to a conventional DNA microarray, in which each genetic sensor spot is designed to respond to a single target organism, in a CSM each sensor spot responds to a group of targets. As a result, significantly fewer total sensor spots are required. In this paper, we study how to design group identifier probes that simultaneously account for both the constraints from the CS theory and the biochemistry of probe-target DNA hybridization. We employ Belief Propagation as a CS recovery method to estimate target concentrations from the microarray intensities.
AB - A Compressive Sensing Microarray (CSM) is a new device for DNA-based identification of target organisms that lever-ages the nascent theory of Compressive Sensing (CS). In contrast to a conventional DNA microarray, in which each genetic sensor spot is designed to respond to a single target organism, in a CSM each sensor spot responds to a group of targets. As a result, significantly fewer total sensor spots are required. In this paper, we study how to design group identifier probes that simultaneously account for both the constraints from the CS theory and the biochemistry of probe-target DNA hybridization. We employ Belief Propagation as a CS recovery method to estimate target concentrations from the microarray intensities.
KW - Compressive sensing
KW - DNA microarrays
KW - Hybridization affinity
KW - Probe design
UR - http://www.scopus.com/inward/record.url?scp=50249137172&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50249137172&partnerID=8YFLogxK
U2 - 10.1109/CAMSAP.2007.4497985
DO - 10.1109/CAMSAP.2007.4497985
M3 - Conference contribution
AN - SCOPUS:50249137172
SN - 9781424417148
T3 - 2007 2nd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMPSAP
SP - 141
EP - 144
BT - 2007 2nd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMPSAP
T2 - 2007 2nd IEEE International Workshop on Computational Advances in Multi-Sensor Adaptive Processing, CAMPSAP
Y2 - 12 December 2007 through 14 December 2007
ER -