Design of functional metalloproteins

Yi Lu, Natasha Yeung, Nathan Sieracki, Nicholas M. Marshall

Research output: Contribution to journalReview article

Abstract

Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their variants, but also can result in new metalloenzymes for biotechnological and pharmaceutical applications. Although it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly in functional design, owing to recent advances in areas such as computational and structural biology.

Original languageEnglish (US)
Pages (from-to)855-862
Number of pages8
JournalNature
Volume460
Issue number7257
DOIs
StatePublished - Aug 13 2009

Fingerprint

Metalloproteins
Photosynthesis
Computational Biology
Water
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Lu, Y., Yeung, N., Sieracki, N., & Marshall, N. M. (2009). Design of functional metalloproteins. Nature, 460(7257), 855-862. https://doi.org/10.1038/nature08304

Design of functional metalloproteins. / Lu, Yi; Yeung, Natasha; Sieracki, Nathan; Marshall, Nicholas M.

In: Nature, Vol. 460, No. 7257, 13.08.2009, p. 855-862.

Research output: Contribution to journalReview article

Lu, Y, Yeung, N, Sieracki, N & Marshall, NM 2009, 'Design of functional metalloproteins', Nature, vol. 460, no. 7257, pp. 855-862. https://doi.org/10.1038/nature08304
Lu Y, Yeung N, Sieracki N, Marshall NM. Design of functional metalloproteins. Nature. 2009 Aug 13;460(7257):855-862. https://doi.org/10.1038/nature08304
Lu, Yi ; Yeung, Natasha ; Sieracki, Nathan ; Marshall, Nicholas M. / Design of functional metalloproteins. In: Nature. 2009 ; Vol. 460, No. 7257. pp. 855-862.
@article{4a0b6ccf9c1147d991476761b4755450,
title = "Design of functional metalloproteins",
abstract = "Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their variants, but also can result in new metalloenzymes for biotechnological and pharmaceutical applications. Although it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly in functional design, owing to recent advances in areas such as computational and structural biology.",
author = "Yi Lu and Natasha Yeung and Nathan Sieracki and Marshall, {Nicholas M.}",
year = "2009",
month = "8",
day = "13",
doi = "10.1038/nature08304",
language = "English (US)",
volume = "460",
pages = "855--862",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7257",

}

TY - JOUR

T1 - Design of functional metalloproteins

AU - Lu, Yi

AU - Yeung, Natasha

AU - Sieracki, Nathan

AU - Marshall, Nicholas M.

PY - 2009/8/13

Y1 - 2009/8/13

N2 - Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their variants, but also can result in new metalloenzymes for biotechnological and pharmaceutical applications. Although it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly in functional design, owing to recent advances in areas such as computational and structural biology.

AB - Metalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new metalloproteins. Doing so not only can reveal hidden structural features that may be missing from studies of native metalloproteins and their variants, but also can result in new metalloenzymes for biotechnological and pharmaceutical applications. Although it is much more challenging to design metalloproteins than non-metalloproteins, much progress has been made in this area, particularly in functional design, owing to recent advances in areas such as computational and structural biology.

UR - http://www.scopus.com/inward/record.url?scp=68949195832&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68949195832&partnerID=8YFLogxK

U2 - 10.1038/nature08304

DO - 10.1038/nature08304

M3 - Review article

C2 - 19675646

AN - SCOPUS:68949195832

VL - 460

SP - 855

EP - 862

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7257

ER -