Design of colorimetric biosensors with DNAzymes and nanoparticles

Juewen Liu, Yi Lu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

DNAzymes are DNA molecules with catalytic activities. Analyte-specific DNAzymes can be isolated with a combinatorial biology method called in vitro selection. For example, a Pb2+-specific DNAzyme cleaves its substrate DNA only in the presence of Pb2+. By attaching DNA-functionalized gold nanoparticles to DNAzymes, colorimetric sensors can be designed based on the different colors displayed by the different aggregate states of gold nanoparticles.

Original languageEnglish (US)
Title of host publication2nd Conference on Foundations of Nanoscience
Subtitle of host publicationSelf-Assembled Architectures and Devices, FNANO 2005
Pages226-227
Number of pages2
StatePublished - 2005
Event2nd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2005 - Snowbird, UT, United States
Duration: Apr 24 2005Apr 28 2005

Other

Other2nd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2005
CountryUnited States
CitySnowbird, UT
Period4/24/054/28/05

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Fingerprint Dive into the research topics of 'Design of colorimetric biosensors with DNAzymes and nanoparticles'. Together they form a unique fingerprint.

  • Cite this

    Liu, J., & Lu, Y. (2005). Design of colorimetric biosensors with DNAzymes and nanoparticles. In 2nd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2005 (pp. 226-227)