Design and implementation of new, silicon-based, cross-coupling reactions: Importance of silicon-oxygen bonds

Scott E. Denmark, Ramzi F. Sweis

Research output: Contribution to journalArticlepeer-review

Abstract

This Account chronicles the conceptual development, proof of principle, exploration of scope, and mechanistic investigations of a newly developed class of palladium-catalyzed cross-coupling reactions of silicon derivatives. Under the influence of fluoride activation a myriad of oxygen-containing silicon moieties undergo mild and stereospecific cross-coupling. The diversity of methods for introduction of silicon groupings into organic molecules and the range of organic electrophiles that can be used are outlined.

Original languageEnglish (US)
Pages (from-to)835-846
Number of pages12
JournalAccounts of chemical research
Volume35
Issue number10
DOIs
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Chemistry(all)

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