Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies

G. Fu, L. J. Meng, C. T. Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we report the design and feasibility study of a high resolution and high sensitivity SPECT (GammaCube) system for mouse brain imaging. The system consists of six high resolution gamma ray detectors, arranged in cubic geometry, and a truncated spherical aperture with multiple pinholes, which offers a relatively uniform 4π angular coverage around the object. The proposed Gamma-Cube system is based on the so-called energy-resolved photon-counting (ERPC) detector that consists of multiple pixilated CdTe detectors bump-bonded to ERPC readout ASICs that are 1.1×2.2cm in size with a pixel pitch of 350μm×350μm. In this study, we used Monte Carlo simulation to optimize system geometry and multiple-pinhole patterns for detection of a tiny amount of radioactivity in mouse brain.

Original languageEnglish (US)
Title of host publication2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
Pages3855-3860
Number of pages6
DOIs
StatePublished - Dec 1 2008
Event2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 - Dresden, Germany
Duration: Oct 19 2008Oct 25 2008

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008
CountryGermany
CityDresden
Period10/19/0810/25/08

Fingerprint

Feasibility Studies
Single-Photon Emission-Computed Tomography
Photons
brain
mice
pinholes
sensitivity
high resolution
Gamma Rays
detectors
counting
Brain
Neuroimaging
Radioactivity
application specific integrated circuits
photons
geometry
radioactivity
readout
apertures

Keywords

  • ERPC
  • Gamma-cube
  • Spherical aperture

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Fu, G., Meng, L. J., & Chen, C. T. (2008). Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008 (pp. 3855-3860). [4774122] (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774122

Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies. / Fu, G.; Meng, L. J.; Chen, C. T.

2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. p. 3855-3860 4774122 (IEEE Nuclear Science Symposium Conference Record).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Fu, G, Meng, LJ & Chen, CT 2008, Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies. in 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008., 4774122, IEEE Nuclear Science Symposium Conference Record, pp. 3855-3860, 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008, Dresden, Germany, 10/19/08. https://doi.org/10.1109/NSSMIC.2008.4774122
Fu G, Meng LJ, Chen CT. Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies. In 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. p. 3855-3860. 4774122. (IEEE Nuclear Science Symposium Conference Record). https://doi.org/10.1109/NSSMIC.2008.4774122
Fu, G. ; Meng, L. J. ; Chen, C. T. / Design and feasibility study of gamma-cube - A high resolution and high sensitivity SPECT system for in vivo mouse brain studies. 2008 IEEE Nuclear Science Symposium Conference Record, NSS/MIC 2008. 2008. pp. 3855-3860 (IEEE Nuclear Science Symposium Conference Record).
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