Design and feasibility study of a single photon emission microscope system for small animal 1-125 imaging

L. J. Meng; N. H. Clinthorne; S. Skinner; R. V. Hay; M. Gross

doi:10.1109/TNS.2006.871405

Design and feasibility study of a single photon emission microscope system for small animal 1-125 imaging

L. J. Meng, N. H. Clinthorne, S. Skinner, R. V. Hay, M. Gross

Research output: Contribution to journal › Article › peer-review

Abstract

This paper presents a design study of a single photon emission microscope (SPEM) system for small animal imaging using 1-125 labelled radiotracers. This system is based on the use of a very-high resolution gamma camera coupled to a converging non-multiplexing multiple pinhole collimator. This enables one to "zoom" into a small local region inside the object to extract imaging information with a very high spatial resolution and a reasonable sensitivity for gamma rays emitted from this local region. The SPEM system also includes a pinhole (or multiple pinhole) gamma camera that has a full angular coverage of the entire object. The designed imaging spatial resolution for the SPEM system is between 250 μm to 500 μm FWHM.

Original language	English (US)
Article number	1645012
Pages (from-to)	1168-1178
Number of pages	11
Journal	IEEE Transactions on Nuclear Science
Volume	53
Issue number	3
DOIs	https://doi.org/10.1109/TNS.2006.871405
State	Published - Jun 2006
Externally published	Yes

Keywords

Converging non-multiplexing multiple pinhole aperture
Microscope
Very-high spatial resolution gamma camera

ASJC Scopus subject areas

Nuclear and High Energy Physics
Nuclear Energy and Engineering
Electrical and Electronic Engineering

Online availability

10.1109/TNS.2006.871405

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Design and feasibility study of a single photon emission microscope system for small animal 1-125 imaging

Abstract

Keywords

ASJC Scopus subject areas

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