Design and engineering of metalloproteins containing unnatural amino acids or non-native metal-containing cofactors

Research output: Contribution to journalReview article

Abstract

An emerging branch of metalloprotein design and engineering is on the horizon, where unnatural amino acids or non-native metal-containing cofactors are employed in the design and engineering process. These endeavors have been shown to be quite effective in elucidating the precise roles of key residues in protein structures and functions, in providing guiding principles on protein design, in fine-tuning the protein properties to an unprecedented level, and in expanding the repertoire of protein functionalities, and thus its range of applications.

Original languageEnglish (US)
Pages (from-to)118-126
Number of pages9
JournalCurrent Opinion in Chemical Biology
Volume9
Issue number2
DOIs
StatePublished - Apr 2005

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Metalloproteins
Metals
Amino Acids
Proteins
Tuning

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Design and engineering of metalloproteins containing unnatural amino acids or non-native metal-containing cofactors. / Lu, Yi.

In: Current Opinion in Chemical Biology, Vol. 9, No. 2, 04.2005, p. 118-126.

Research output: Contribution to journalReview article

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