Design and engineering of artificial oxygen-activating metalloenzymes

Flavia Nastri, Marco Chino, Ornella Maglio, Ambika Bhagi-Damodaran, Yi Lu, Angela Lombardi

Research output: Contribution to journalReview articlepeer-review


Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.

Original languageEnglish (US)
Pages (from-to)5020-5054
Number of pages35
JournalChemical Society Reviews
Issue number18
StatePublished - Sep 21 2016

ASJC Scopus subject areas

  • Chemistry(all)


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