Design and development of polymers for gene delivery

Daniel W. Pack, Allan S. Hoffman, Suzie Pun, Patrick S. Stayton

Research output: Contribution to journalReview articlepeer-review


The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure-function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative polymer chemists, it is likely that polymer-based gene-delivery systems will become an important tool for human gene therapy.

Original languageEnglish (US)
Pages (from-to)581-593
Number of pages13
JournalNature Reviews Drug Discovery
Issue number7
StatePublished - Jul 2005

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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