Design and biological effects of a vaginally administered gel containing the GnRH agonist, triptorelin, for synchronizing ovulation in swine

Robert Victor Knox, K. R. Stewart, W. L. Flowers, M. E. Swanson, S. K. Webel, R. R. Kraeling

Research output: Contribution to journalArticle

Abstract

A novel gel formulation was selected for intravaginal delivery of the GnRH agonist (triptorelin) for synchronizing ovulation in pigs. Studies with gilt models were used to assess LH response profiles. The lowest dose of triptorelin that induced the most gilts to show an LH surge was 100 μg in 1.2% methylcellulose gel. This formulation had a similar effect in weaned sows while also advancing ovulation. The timing of administration was evaluated in sows after weaning. Administration at 96 h induced more sows to ovulate (58%) by 48 h compared to treatment at estrus (45%) or for controls (34%), but the desired level of ovulation synchrony was not achieved. As a result, greater doses of triptorelin were tested and 200 μg given at 96 h after weaning, induced 81% of sows to ovulate within 48 h after treatment. The best synchrony of ovulation occurred when given at 96 h after weaning compared to earlier or later intervals. The optimum time to give a single fixed time AI (SFT-AI) after administration of 200 μg of triptorelin in 1.2% gel (OvuGel®) at 96 h after weaning was tested. A SFT-AI at 22 ± 2 h after OvuGel achieved the highest fertility and was practical for staff during the normal work day. In field trials, a SFT-AI 22 ± 2 h after all weaned sows were treated with OvuGel improved (P = 0.04) farrowing rate to 82.5% compared to control sows weaned (80.1%), with no effect on numbers of pigs born alive (12.1). Research continues for identifying the advantages for use of OvuGel in different production systems, and potential application for use in gilts.

Original languageEnglish (US)
Pages (from-to)44-52
Number of pages9
JournalTheriogenology
Volume112
DOIs
StatePublished - May 2018

Fingerprint

Triptorelin Pamoate
Ovulation
Weaning
Gonadotropin-Releasing Hormone
agonists
sows
ovulation
Swine
Gels
gels
swine
weaning
gilts
Methylcellulose
Estrus
farrowing rate
Fertility
methylcellulose
work schedules
dosage

Keywords

  • AI
  • Fertility
  • OvuGel
  • Ovulation
  • Pig
  • Synchronization

ASJC Scopus subject areas

  • Small Animals
  • Food Animals
  • Animal Science and Zoology
  • Equine

Cite this

Design and biological effects of a vaginally administered gel containing the GnRH agonist, triptorelin, for synchronizing ovulation in swine. / Knox, Robert Victor; Stewart, K. R.; Flowers, W. L.; Swanson, M. E.; Webel, S. K.; Kraeling, R. R.

In: Theriogenology, Vol. 112, 05.2018, p. 44-52.

Research output: Contribution to journalArticle

Knox, Robert Victor ; Stewart, K. R. ; Flowers, W. L. ; Swanson, M. E. ; Webel, S. K. ; Kraeling, R. R. / Design and biological effects of a vaginally administered gel containing the GnRH agonist, triptorelin, for synchronizing ovulation in swine. In: Theriogenology. 2018 ; Vol. 112. pp. 44-52.
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