Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor

Keyphrases

• Synaptic Response 100%
• Nicotinic Receptors 100%
• Desensitization 100%
• Gain-of-function mutation 100%
• Acetylcholine 57%
• Acetylcholine Receptor (AChR) 57%
• Physiological Condition 14%
• High Concentration 14%
• Neurotransmitters 14%
• Structure Function 14%
• Frequency Dependence 14%
• Vertebrates 14%
• Dissociation 14%
• Kinetic Scheme 14%
• Mutagenesis 14%
• Neuromuscular Junction 14%
• Neurotransmitter Release 14%
• Current Response 14%
• Synaptic Transmission 14%
• Cause of Disease 14%
• Dissociation Rate Constant 14%
• Membrane Patch 14%
• Channel Opening 14%
• Repetitive Stimulation 14%
• Fine Balance 14%
• Desensitized State 14%
• Channel Closure 14%
• Naturally Occurring Disease 14%

Immunology and Microbiology

• Nicotinic Acetylcholine Receptor 100%
• Structure Activity Relation 50%
• Neuromuscular Junction 50%
• Mutagenesis 50%
• Wild Type 50%
• Pulse Rate 50%
• Neurotransmitter Release 50%
• Gain of Function Mutation 50%
• Synaptic Transmission 50%
• Dissociation Rate Constant 50%

Biochemistry, Genetics and Molecular Biology

• Acetylcholine 100%
• Nicotinic Receptor 100%
• Neurotransmitter 25%
• Structure Activity Relation 25%
• Mutagenesis 25%
• Wild Type 25%
• Pulse Rate 25%
• Neurotransmitter Release 25%
• Synaptic Transmission 25%
• Dissociation Rate Constant 25%
• Gain of Function Mutation 25%