Depth resolution properties of in-line X-ray phase-contrast Tomosynthesis

Huifeng Guan, Qiaofeng Xu, Alfred Garson, Mark A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In-line x-ray phase-contrast (XPC) Tomosynthesis combines The concepts of Tomosynthesis and in-line XPC imaging To utilize The advantages of both for biological imaging applications. Tomosynthesis permits reductions in acquisition Times compared with conventional Tomography scans while in-line XPC imaging provides high contrast and resolution in images of weakly absorbing materials. In This work, we develop an advanced iterative algorithm as an approach for dealing with The incomplete (and often noisy) data inherent To XPC Tomosynthesis. We also investigate The depth resolution properties of XPC Tomosynthesis and demonstrate That The z-resolution properties of XPC Tomosynthesis is superior To That of conventional absorption-based Tomosynthesis. More specifically, we find in-plane structures display strong boundary-enhancement while out-of-plane structures do not. This effect can facilitate The identification of in-plane structures.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2014
Subtitle of host publicationPhysics of Medical Imaging
ISBN (Print)9780819498267
StatePublished - Jan 1 2014
Externally publishedYes
EventMedical Imaging 2014: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 17 2014Feb 20 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2014: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego, CA


  • image reconstruction
  • Tomosynthesis
  • X-ray phase-contrast

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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