Depth Correction of 3D NanoSIMS Images Shows Intracellular Lipid and Cholesterol Distributions while Capturing the Effects of Differential Sputter Rate

Engineering & Materials Science

• Depth profiling 100%
• Cholesterol 94%
• Lipids 81%
• Metabolites 27%
• Focused ion beams 14%
• Electron microscopy 13%
• Sputtering 12%
• Topography 11%
• Electrons 10%
• Nanoparticles 10%
• Ions 9%
• Membranes 8%
• Visualization 7%

Physics & Astronomy

• cholesterol 78%
• lipids 59%
• drugs 20%
• cells 18%
• metabolites 17%
• organelles 8%
• topography 6%
• electron microscopy 5%
• spatial resolution 5%
• sputtering 5%
• ion beams 5%
• atomic force microscopy 5%
• membranes 4%
• nanoparticles 4%
• sensitivity 3%
• ions 3%
• electrons 2%

Chemical Compounds

• Depth Profiling 76%
• Lipid 42%
• Drug Metabolite 27%
• Sputtering 10%
• Drug Carrier 10%
• Electron Microscopy 8%
• Shape 6%
• Electron Particle 5%
• Ion 4%
• Application 3%