Depression and Anxious Apprehension Distinguish Frontocingulate Cortical Activity During Top-Down Attentional Control

Rebecca Levin Silton, Wendy Heller, Anna S. Engels, David N. Towers, Jeffrey M. Spielberg, J. Christopher Edgar, Sarah M. Sass, Jennifer L. Stewart, Bradley P. Sutton, Marie T. Banich, Gregory A. Miller

Research output: Contribution to journalArticle

Abstract

A network consisting of left dorsolateral prefrontal cortex (LDLPFC) and dorsal anterior cingulate cortex (dACC) has been implicated in top-down attentional control. Few studies have systematically investigated how this network is altered in psychopathology, despite evidence that depression and anxiety are associated with attentional control impairments. Functional MRI and dense-array event-related brain potential (ERP) data were collected in separate sessions from 100 participants during a color-word Stroop task. Functional MRI results guided ERP source modeling to characterize the time course of activity in LDLPFC (300-440 ms) and dACC (520-680 ms). At low levels of depression, LDLPFC activity was indirectly related to Stroop interference and only via dACC activity. In contrast, at high levels of depression, dACC did not play an intervening role, and increased LDLPFC activity was directly related to decreased Stroop interference. Specific to high levels of anxious apprehension, higher dACC activity was related to more Stroop interference. Results indicate that depression and anxious apprehension modulate temporally and functionally distinct aspects of the frontocingulate network involved in top-down attention control.

Original languageEnglish (US)
Pages (from-to)272-285
Number of pages14
JournalJournal of abnormal psychology
Volume120
Issue number2
DOIs
StatePublished - May 2011

Keywords

  • Anxious apprehension
  • Attention
  • DACC
  • Depression
  • LDLPFC

ASJC Scopus subject areas

  • Clinical Psychology

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    Levin Silton, R., Heller, W., Engels, A. S., Towers, D. N., Spielberg, J. M., Edgar, J. C., Sass, S. M., Stewart, J. L., Sutton, B. P., Banich, M. T., & Miller, G. A. (2011). Depression and Anxious Apprehension Distinguish Frontocingulate Cortical Activity During Top-Down Attentional Control. Journal of abnormal psychology, 120(2), 272-285. https://doi.org/10.1037/a0023204