TY - JOUR
T1 - Depletion interactions in the protein limit
T2 - Effects of polymer density fluctuations
AU - Kulkarni, Amit M.
AU - Chatterjee, Avik P.
AU - Schweizer, Kenneth S.
AU - Zukoski, Charles F.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - We report the first observations of nonmonotonic changes in the second virial coefficients of protein solutions, B2, as the concentration of nonadsorbing polymer is increased. The observed minimum in B2 cannot be predicted from standard depletion interaction energy models and is closely associated with proximity to the lower critical solution temperature of the polymer solution. The location, depth, and molecular weight dependence of the minima are captured by the thermal polymer reference interaction site model for depletion interactions, where the polymer mesh size is a function of temperature.
AB - We report the first observations of nonmonotonic changes in the second virial coefficients of protein solutions, B2, as the concentration of nonadsorbing polymer is increased. The observed minimum in B2 cannot be predicted from standard depletion interaction energy models and is closely associated with proximity to the lower critical solution temperature of the polymer solution. The location, depth, and molecular weight dependence of the minima are captured by the thermal polymer reference interaction site model for depletion interactions, where the polymer mesh size is a function of temperature.
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U2 - 10.1103/PhysRevLett.83.4554
DO - 10.1103/PhysRevLett.83.4554
M3 - Article
AN - SCOPUS:0001765144
SN - 0031-9007
VL - 83
SP - 4554
EP - 4557
JO - Physical Review Letters
JF - Physical Review Letters
IS - 22
ER -