Deoxystreptamine dimers bind to RNA hairpin loops

Xianjun Liu, Jason R. Thomas, Paul J. Hergenrother

Research output: Contribution to journalArticlepeer-review

Abstract

RNA is known to have multiple roles in critical cellular functions. Thus, there is great potential for RNA-binding small molecules as both therapeutic agents and cellular probes. Unfortunately, the multiple secondary structures that RNA can adopt have caused difficulty in the development of a general paradigm for RNA-small molecule binding. In particular, the standard RNA-binding compounds such as aminoglycosides do not generally bind RNA hairpin loops, a widespread and vitally important secondary structural motif. In this manuscript we report that dimers of deoxystreptamine bind to RNA hairpin loops with affinities rivaling that of RNA-aminoglycoside interactions.

Original languageEnglish (US)
Pages (from-to)9196-9197
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number30
DOIs
StatePublished - Aug 4 2004

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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