Deoligomerization: A new route to lactams from unsaturated amides via radical oligomerization

Li Liu, Xing Wang, Chaozhong Li

Research output: Contribution to journalArticle

Abstract

(Matrix presented) Triethylborane-initiated atom transfer radical oligomerization of N-allyl or N-(3-butenyl)iodoacetamides followed by treatment with hydrochloric acid and subsequent neutralization with K2CO 3 led to the formation of the corresponding 5-hydroxyl-substituted δ-lactams or caprolactams, respectively. This oligomerization-deoligomerization sequence serves as an alternative to the corresponding intramolecular cyclization reactions.

Original languageEnglish (US)
Pages (from-to)361-363
Number of pages3
JournalOrganic Letters
Volume5
Issue number3
DOIs
StatePublished - Feb 6 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Deoligomerization: A new route to lactams from unsaturated amides via radical oligomerization'. Together they form a unique fingerprint.

  • Cite this