Deletion of ALS5, ALS6 or ALS7 increases adhesion of Candida albicans to human vascular endothelial and buccal epithelial cells

Xiaomin Zhao, Soon Hwan Oh, Lois L. Hoyer

Research output: Contribution to journalArticlepeer-review

Abstract

Candida albicans yeast forms deleted for ALS5, ALS6 or ALS7 are more adherent than a relevant control strain to human vascular endothelial cell monolayers and buccal epithelial cells. In the buccal and vaginal reconstituted human epithelium (RHE) disease models, however, mutant and control strains caused a similar degree of tissue destruction. Deletion of ALS5 or ALS6 significantly slowed growth of the mutant strain; this phenotype was not affected by addition of excess uridine to the culture medium. These studies demonstrate similar phenotypic characteristics for the als5Δ/als5Δ, als6Δ/als6Δ and als7Δ/ als7Δ strains that are not observed in any of the other C. albicans alsΔ/alsΔ isolates.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalMedical Mycology
Volume45
Issue number5
DOIs
StatePublished - Aug 2007

Keywords

  • ALS gene family
  • Adhesion
  • Candida albicans
  • Host-pathogen interaction

ASJC Scopus subject areas

  • Infectious Diseases

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