Abstract
Candida albicans yeast forms deleted for ALS5, ALS6 or ALS7 are more adherent than a relevant control strain to human vascular endothelial cell monolayers and buccal epithelial cells. In the buccal and vaginal reconstituted human epithelium (RHE) disease models, however, mutant and control strains caused a similar degree of tissue destruction. Deletion of ALS5 or ALS6 significantly slowed growth of the mutant strain; this phenotype was not affected by addition of excess uridine to the culture medium. These studies demonstrate similar phenotypic characteristics for the als5Δ/als5Δ, als6Δ/als6Δ and als7Δ/ als7Δ strains that are not observed in any of the other C. albicans alsΔ/alsΔ isolates.
Original language | English (US) |
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Pages (from-to) | 429-434 |
Number of pages | 6 |
Journal | Medical Mycology |
Volume | 45 |
Issue number | 5 |
DOIs | |
State | Published - Aug 2007 |
Keywords
- ALS gene family
- Adhesion
- Candida albicans
- Host-pathogen interaction
ASJC Scopus subject areas
- Infectious Diseases