Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles

Philippe Marmottant, Thierry Biben, Sascha Hilgenfeldt

Research output: Contribution to journalArticle

Abstract

Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the local tension becomes negative, leading to buckling and tip formation near a pole of the vesicle. We experimentally check these predictions in the case of strong acoustic streaming flow generated near ultrasound-driven microbubbles, such as those used in medical applications.

Original languageEnglish (US)
Pages (from-to)1781-1800
Number of pages20
JournalProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume464
Issue number2095
DOIs
StatePublished - Jul 8 2008
Externally publishedYes

Fingerprint

Rupture
Vesicles
Shear flow
Shear Flow
Ultrasound
Lipids
shear flow
lipids
Ultrasonics
Acoustic streaming
Membranes
Medical applications
Shear deformation
acoustic streaming
membranes
Buckling
Elongation
Poles
buckling
predictions

Keywords

  • Lipid vesicles
  • Microfluidics
  • Shear flow

ASJC Scopus subject areas

  • Mathematics(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles. / Marmottant, Philippe; Biben, Thierry; Hilgenfeldt, Sascha.

In: Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 464, No. 2095, 08.07.2008, p. 1781-1800.

Research output: Contribution to journalArticle

@article{e192e0a2b11a4fdf947724dd2f8649f0,
title = "Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles",
abstract = "Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the local tension becomes negative, leading to buckling and tip formation near a pole of the vesicle. We experimentally check these predictions in the case of strong acoustic streaming flow generated near ultrasound-driven microbubbles, such as those used in medical applications.",
keywords = "Lipid vesicles, Microfluidics, Shear flow",
author = "Philippe Marmottant and Thierry Biben and Sascha Hilgenfeldt",
year = "2008",
month = "7",
day = "8",
doi = "10.1098/rspa.2007.0362",
language = "English (US)",
volume = "464",
pages = "1781--1800",
journal = "Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences",
issn = "0080-4630",
publisher = "Royal Society of London",
number = "2095",

}

TY - JOUR

T1 - Deformation and rupture of lipid vesicles in the strong shear flow generated by ultrasound-driven microbubbles

AU - Marmottant, Philippe

AU - Biben, Thierry

AU - Hilgenfeldt, Sascha

PY - 2008/7/8

Y1 - 2008/7/8

N2 - Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the local tension becomes negative, leading to buckling and tip formation near a pole of the vesicle. We experimentally check these predictions in the case of strong acoustic streaming flow generated near ultrasound-driven microbubbles, such as those used in medical applications.

AB - Considering the elastic response of the membrane of a lipid vesicle (artificial cell) in an arbitrary three-dimensional shear flow, we derive analytical predictions of vesicle shape and membrane tension for vesicles close to a spherical shape. Large amplitude deviations from sphericity are described using boundary integral numerical simulations. Two possible modes of vesicle rupture are found and compared favourably with experiments: (i) for large enough shear rates the tension locally exceeds a rupture threshold and a pore opens at the waist of the vesicle and (ii) for large elongations the local tension becomes negative, leading to buckling and tip formation near a pole of the vesicle. We experimentally check these predictions in the case of strong acoustic streaming flow generated near ultrasound-driven microbubbles, such as those used in medical applications.

KW - Lipid vesicles

KW - Microfluidics

KW - Shear flow

UR - http://www.scopus.com/inward/record.url?scp=43949139933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43949139933&partnerID=8YFLogxK

U2 - 10.1098/rspa.2007.0362

DO - 10.1098/rspa.2007.0362

M3 - Article

VL - 464

SP - 1781

EP - 1800

JO - Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

JF - Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences

SN - 0080-4630

IS - 2095

ER -