TY - JOUR
T1 - Defining and studying B cell receptor and TCR interactions
AU - Rappazzo, C. Garrett
AU - Fernandez-Quintero, Monica L.
AU - Mayer, Andreas
AU - Wu, Nicholas C.
AU - Greiff, Victor
AU - Guthmiller, Jenna J.
N1 - Publisher Copyright:
© 2023 by The American Association of Immunologists, Inc.
PY - 2023/8/1
Y1 - 2023/8/1
N2 - BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by which the adaptive immune system recognizes foreign and self-Antigens, playing an integral part in host defense, as well as the emergence of autoimmunity. Importantly, the interaction between AIRs and their cognate Ags defies a simple key-in-lock paradigm and is instead a complex many-To-many mapping between an individual's massively diverse AIR repertoire, and a similarly diverse antigenic space. Understanding how adaptive immunity balances specificity with epitopic coverage is a key challenge for the field, and terms such as broad specificity, cross-reactivity, and polyreactivity remain ill-defined and are used inconsistently. In this Immunology Notes and Resources article, a group of experimental, structural, and computational immunologists define commonly used terms associated with AIR binding, describe methodologies to study these binding modes, as well as highlight the implications of these different binding modes for therapeutic design. The Journal of Immunology, 2023, 211: 311-322.
AB - BCRs (Abs) and TCRs (or adaptive immune receptors [AIRs]) are the means by which the adaptive immune system recognizes foreign and self-Antigens, playing an integral part in host defense, as well as the emergence of autoimmunity. Importantly, the interaction between AIRs and their cognate Ags defies a simple key-in-lock paradigm and is instead a complex many-To-many mapping between an individual's massively diverse AIR repertoire, and a similarly diverse antigenic space. Understanding how adaptive immunity balances specificity with epitopic coverage is a key challenge for the field, and terms such as broad specificity, cross-reactivity, and polyreactivity remain ill-defined and are used inconsistently. In this Immunology Notes and Resources article, a group of experimental, structural, and computational immunologists define commonly used terms associated with AIR binding, describe methodologies to study these binding modes, as well as highlight the implications of these different binding modes for therapeutic design. The Journal of Immunology, 2023, 211: 311-322.
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U2 - 10.4049/jimmunol.2300136
DO - 10.4049/jimmunol.2300136
M3 - Article
C2 - 37459189
AN - SCOPUS:85165020149
SN - 0022-1767
VL - 211
SP - 311
EP - 322
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -