Deeper understanding of carboxylase

James H. Morrissey

Research output: Contribution to journalComment/debate

Abstract

In this issue of Blood, Tie et al report the development of a cleverly engineered, cell-based system for studying mutations in γ-glutamyl carboxylase (GGCX), the enzyme responsible for converting glutamate residues in certain proteins to γ-carboxyglutamate (Gla).1 They use this cell-based assay system to help explain the clinical manifestations of some otherwise puzzling GGCX gene mutations in humans that cause phenotypes ranging from severe bleeding to Keutel syndrome.

Original languageEnglish (US)
Pages (from-to)1841-1842
Number of pages2
JournalBlood
Volume127
Issue number15
DOIs
StatePublished - Apr 14 2016

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Glutamic Acid
Assays
Blood
Genes
Mutation
Enzymes
Proteins
Hemorrhage
Phenotype
glutamyl carboxylase
Keutel syndrome

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Deeper understanding of carboxylase. / Morrissey, James H.

In: Blood, Vol. 127, No. 15, 14.04.2016, p. 1841-1842.

Research output: Contribution to journalComment/debate

Morrissey, JH 2016, 'Deeper understanding of carboxylase', Blood, vol. 127, no. 15, pp. 1841-1842. https://doi.org/10.1182/blood-2016-02-694927
Morrissey, James H. / Deeper understanding of carboxylase. In: Blood. 2016 ; Vol. 127, No. 15. pp. 1841-1842.
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