Decreased dopamine turnover in the median eminence in response to suckling in the lactating rat

Michael Selmanoff, Phyllis M. Wise

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of suckling on the turnover of dopamine (DA) and norepinephrine (NE) were studied in terminal projection fields of the tuberoinfundibular (median eminence, ME), nigrostriatal (caudate nucleus, CN), incertohypothalamic (medial preoptic nucleus, MPN) and mesolimbic (nucleus accumbens, NA) dopaminergic neurons. Decreased dopamine turnover in the median eminence was found in suckled compared with nonsuckled rats at 10 days postpartum. This effect was specific as dopamine turnover in the CN, NA and MPN and norepinephrine turnover in the ME, NA and MPN were not affected by suckling. The suckling-induced prolactin response is markedly blunted in rats 20 days postpartum. In these rats, median eminence dopamine turnover did not decrease significantly in response to suckling. These results are consistent with the hypothesis that median eminence dopamine is a physiological prolactin inhibitory factor mediating suckling-induced prolactin release.

Original languageEnglish (US)
Pages (from-to)101-115
Number of pages15
JournalBrain Research
Volume212
Issue number1
DOIs
StatePublished - May 11 1981
Externally publishedYes

Keywords

  • dopamine
  • hypothalamus
  • lactation
  • median eminence
  • suckling

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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