Decomposition and solubility of H2O2: Implications in exhaled breath condensate collection

Shin Fang Chen, Mary-Grace Danao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hydrogen peroxide (H2O2) is one of the metabolic end products present in exhaled breath and exhaled breath condensate. High levels of H2O2 found in breath condensate are an indicator of airway inflammation and could be used for monitoring the condition of patients with chronic obstructive pulmonary disease. However, sampling conditions such as breath temperature, condensing temperature, flow rate and collection time can affect the intrinsic properties of H2O2 - its solubility, volatility, and decomposition rate. Sudden decreases to H2O 2 concentration may be due to the sampling conditions instead of the patient's health status. The decomposition rate and Henry's law constant for saturated H2O2 vapor (RH > 95%) within 22-42°C, which correlates to room temperature and range of human breath temperatures, are needed for better understanding and standardization of breath collection. In this study, we determined the effects of initial H2O2 concentration, temperature, and sampling time on the decomposition rate by comparing electrochemical measurements of H2O2 in simulated breath samples. Results showed the decomposition rate of H2O2 increased as the breath temperature and sampling time increased and the solubility of H 2O2 increased with increasing flow rate and condensing temperature during sampling. Prediction models for H2O2 sensing in exhaled breath sample were developed that could be used in the standardization of exhaled breath condensate collection.

Original languageEnglish (US)
Title of host publicationAmerican Society of Agricultural and Biological Engineers Annual International Meeting 2011, ASABE 2011
PublisherAmerican Society of Agricultural and Biological Engineers
Pages4654-4671
Number of pages18
ISBN (Print)9781618391568
StatePublished - Jan 1 2011
EventAmerican Society of Agricultural and Biological Engineers Annual International Meeting 2011 - Louisville, KY, United States
Duration: Aug 7 2011Aug 10 2011

Publication series

NameAmerican Society of Agricultural and Biological Engineers Annual International Meeting 2011, ASABE 2011
Volume6

Other

OtherAmerican Society of Agricultural and Biological Engineers Annual International Meeting 2011
CountryUnited States
CityLouisville, KY
Period8/7/118/10/11

Keywords

  • Decomposition
  • Exhaled breath condensate
  • Henry's law constant
  • Hydrogen peroxide
  • Solubility

ASJC Scopus subject areas

  • Agronomy and Crop Science

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