Decoding PETase diversity through global landscape profiling: toward superior enzymes for plastic recycling

Yoonjoo Seo; Na Wei

doi:10.1016/j.tibs.2025.03.012

Decoding PETase diversity through global landscape profiling: toward superior enzymes for plastic recycling

Yoonjoo Seo, Na Wei

Research output: Contribution to journal › Short survey › peer-review

Abstract

A recent study by Seo, Hong, Park, et al. maps the global fitness landscape of PET-degrading enzymes, identifying superior PETases for plastic depolymerization. The engineered high-performance variant surpasses benchmarks under industrial conditions. This study provides a powerful framework for enzyme discovery, advancing biocatalytic solutions for plastic waste recycling.

Original language	English (US)
Pages (from-to)	464-466
Number of pages	3
Journal	Trends in Biochemical Sciences
Volume	50
Issue number	6
DOIs	https://doi.org/10.1016/j.tibs.2025.03.012
State	Published - Jun 2025

Keywords

PETase discovery
enzyme engineering
fitness landscape
industrial biocatalysis
plastic biodegradation

ASJC Scopus subject areas

Biochemistry
Molecular Biology

Online availability

10.1016/j.tibs.2025.03.012

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title = "Decoding PETase diversity through global landscape profiling: toward superior enzymes for plastic recycling",

abstract = "A recent study by Seo, Hong, Park, et al. maps the global fitness landscape of PET-degrading enzymes, identifying superior PETases for plastic depolymerization. The engineered high-performance variant surpasses benchmarks under industrial conditions. This study provides a powerful framework for enzyme discovery, advancing biocatalytic solutions for plastic waste recycling.",

keywords = "PETase discovery, enzyme engineering, fitness landscape, industrial biocatalysis, plastic biodegradation",

author = "Yoonjoo Seo and Na Wei",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Ltd",

year = "2025",

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doi = "10.1016/j.tibs.2025.03.012",

language = "English (US)",

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AU - Wei, Na

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N2 - A recent study by Seo, Hong, Park, et al. maps the global fitness landscape of PET-degrading enzymes, identifying superior PETases for plastic depolymerization. The engineered high-performance variant surpasses benchmarks under industrial conditions. This study provides a powerful framework for enzyme discovery, advancing biocatalytic solutions for plastic waste recycling.

AB - A recent study by Seo, Hong, Park, et al. maps the global fitness landscape of PET-degrading enzymes, identifying superior PETases for plastic depolymerization. The engineered high-performance variant surpasses benchmarks under industrial conditions. This study provides a powerful framework for enzyme discovery, advancing biocatalytic solutions for plastic waste recycling.

KW - PETase discovery

KW - enzyme engineering

KW - fitness landscape

KW - industrial biocatalysis

KW - plastic biodegradation

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JO - Trends in Biochemical Sciences

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ER -

Decoding PETase diversity through global landscape profiling: toward superior enzymes for plastic recycling

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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