Decision making in living cells: Lessons from a simple system

Research output: Contribution to journalArticlepeer-review

Abstract

The life cycle of bacteriophage lambda serves as a simplified paradigm for cell-fate decisions. The ongoing quantitative, high-resolution experimental investigation of this life cycle has produced some important insights in recent years. These insights have to do with the way cells choose among alternative fates, how they maintain long-term memory of their gene-expression state, and how they switch from one stable state to another. The recent studies have highlighted the role of spatiotemporal effects in cellular processes and the importance of distinguishing chemical stochasticity from possible hidden variables in cellular decision making.

Original languageEnglish (US)
Pages (from-to)63-80
Number of pages18
JournalAnnual Review of Biophysics
Volume40
Issue number1
DOIs
StatePublished - Jun 9 2011
Externally publishedYes

Keywords

  • bacteriophage lambda
  • Escherichia coli
  • gene expression
  • lysis/lysogeny
  • physics of living cells
  • systems biology

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Bioengineering
  • Biochemistry
  • Cell Biology

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