Decision Making by Temperate Phages

Ido Golding; Seth Coleman; Thu V.P. Nguyen; Tianyou Yao

doi:10.1016/B978-0-12-809633-8.20969-2

Decision Making by Temperate Phages

Ido Golding, Seth Coleman, Thu V.P. Nguyen, Tianyou Yao

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

We describe the process by which, following infection, a temperate phage chooses between two alternative developmental pathways: rapid replication, leading to the release of many new viral particles and death of the infected cell (lysis), versus the shutting off of all virulent functions, resulting in long-term dormancy (lysogeny). We focus on bacteriophage lambda, whose lysis/lysogeny decision serves as paradigm for the way genetic networks drive cell fate decisions, and for the way such decisions become indeterminate (“noisy”) at the single-cell level.

Original language	English (US)
Title of host publication	Encyclopedia of Virology
Subtitle of host publication	Volume 1-5, Fourth Edition
Publisher	Elsevier
Pages	88-97
Number of pages	10
Volume	1-5
ISBN (Electronic)	9780128145166
DOIs	https://doi.org/10.1016/B978-0-12-809633-8.20969-2
State	Published - Jan 1 2020

Keywords

Bacteriophage lambda
Cell fate
Cellular individuality
Decision making
Genetic switch
Induction
Lysis
Lysogeny
Multiplicity of infection
Prophage
Single cell
Stochasticity

ASJC Scopus subject areas

General Immunology and Microbiology

Online availability

10.1016/B978-0-12-809633-8.20969-2

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title = "Decision Making by Temperate Phages",

abstract = "We describe the process by which, following infection, a temperate phage chooses between two alternative developmental pathways: rapid replication, leading to the release of many new viral particles and death of the infected cell (lysis), versus the shutting off of all virulent functions, resulting in long-term dormancy (lysogeny). We focus on bacteriophage lambda, whose lysis/lysogeny decision serves as paradigm for the way genetic networks drive cell fate decisions, and for the way such decisions become indeterminate (“noisy”) at the single-cell level.",

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doi = "10.1016/B978-0-12-809633-8.20969-2",

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AU - Golding, Ido

AU - Coleman, Seth

AU - Nguyen, Thu V.P.

AU - Yao, Tianyou

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N2 - We describe the process by which, following infection, a temperate phage chooses between two alternative developmental pathways: rapid replication, leading to the release of many new viral particles and death of the infected cell (lysis), versus the shutting off of all virulent functions, resulting in long-term dormancy (lysogeny). We focus on bacteriophage lambda, whose lysis/lysogeny decision serves as paradigm for the way genetic networks drive cell fate decisions, and for the way such decisions become indeterminate (“noisy”) at the single-cell level.

AB - We describe the process by which, following infection, a temperate phage chooses between two alternative developmental pathways: rapid replication, leading to the release of many new viral particles and death of the infected cell (lysis), versus the shutting off of all virulent functions, resulting in long-term dormancy (lysogeny). We focus on bacteriophage lambda, whose lysis/lysogeny decision serves as paradigm for the way genetic networks drive cell fate decisions, and for the way such decisions become indeterminate (“noisy”) at the single-cell level.

KW - Bacteriophage lambda

KW - Cell fate

KW - Cellular individuality

KW - Decision making

KW - Genetic switch

KW - Induction

KW - Lysis

KW - Lysogeny

KW - Multiplicity of infection

KW - Prophage

KW - Single cell

KW - Stochasticity

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M3 - Chapter

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PB - Elsevier

ER -

Decision Making by Temperate Phages

Abstract

Keywords

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