Deception through Mimicry: A Cellular Antiviral Strategy

Nicholas C. Wu, Andrew B. Ward

Research output: Contribution to journalShort surveypeer-review

Abstract

Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein. Viruses use mimicry to hijack cellular machinery, but can human cells use mimicry as an antiviral approach? Batra et al. identify a novel antiviral restriction factor, RBBP6, by characterizing the cellular interactome of Ebola virus. RBBP6 targets the Ebola virus transcription factor VP30 by mimicking the binding of Ebola virus nucleoprotein.

Original languageEnglish (US)
Pages (from-to)1728-1729
Number of pages2
JournalCell
Volume175
Issue number7
DOIs
StatePublished - Dec 13 2018
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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