De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly

Brian F. Lin, Rachel S. Marullo, Maxwell J. Robb, Daniel V. Krogstad, Per Antoni, Craig J. Hawker, Luis M. Campos, Matthew V. Tirrell

Research output: Contribution to journalArticle

Abstract

Self-assembling peptide amphiphiles (PAs) have been extensively used in the development of novel biomaterials. Because of their propensity to form cylindrical micelles, their use is limited in applications where small spherical micelles are desired. Here we present a platform method for controlling the self-assembly of biofunctional PAs into spherical 50 nm particles using dendrimers as shape-directing scaffolds. This templating approach results in biocompatible, stable protein-like assemblies displaying peptides with native secondary structure and biofunctionality.

Original languageEnglish (US)
Pages (from-to)3946-3950
Number of pages5
JournalNano letters
Volume11
Issue number9
DOIs
StatePublished - Sep 14 2011

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Keywords

  • Peptide amphiphile
  • biomaterials
  • dendrimer
  • protein analog
  • self-assembly
  • templating

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Lin, B. F., Marullo, R. S., Robb, M. J., Krogstad, D. V., Antoni, P., Hawker, C. J., Campos, L. M., & Tirrell, M. V. (2011). De novo design of bioactive protein-resembling nanospheres via dendrimer-templated peptide amphiphile assembly. Nano letters, 11(9), 3946-3950. https://doi.org/10.1021/nl202220q