@article{8ac488d2c65d438f9a8b71bf3039bce7,
title = "D-Alanine: Distribution, origin, physiological relevance, and implications in disease",
abstract = "D-Alanine (D-Ala) is an unusual endogenous amino acid present in invertebrates and vertebrates. Compared to its L-isomer, the characterization of D-Ala is challenging because of the need for chiral resolution and the low amounts of the D-enantiomer present. With recent improvements in measurement capabilities, research on D-Ala, along with other D-amino acids, has been growing, especially as the functional significance of D-Ala in the mammalian nervous and endocrine systems is becoming known. Here we provide an overview of the distribution, origin, function, and disease implications of D-Ala.",
keywords = "Chiral metabolites, D-alanine, D-amino acids, Disease, Host-microbe, NMDA receptor",
author = "Lee, {Cindy J.} and Qiu, {Tian A.} and Sweedler, {Jonathan V.}",
note = "Funding Information: The authors gratefully acknowledge support by the American Diabetes Association Pathway to Stop Diabetes Grant No. 1-18-VSN-19 . T.A.Q. acknowledges support by a Beckman Institute Postdoctoral Fellowship, funded by a Beckman Foundation gift to the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. We thank Prof. Kenji Hamase for providing the high-resolution images in Figs. 4 and 5 . Funding Information: The authors gratefully acknowledge support by the American Diabetes Association Pathway to Stop Diabetes Grant No. 1-18-VSN-19. T.A.Q. acknowledges support by a Beckman Institute Postdoctoral Fellowship, funded by a Beckman Foundation gift to the Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign. We thank Prof. Kenji Hamase for providing the high-resolution images in Figs. 4 and 5. Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",
year = "2020",
month = nov,
doi = "10.1016/j.bbapap.2020.140482",
language = "English (US)",
volume = "1868",
journal = "BBA - Protein Structure",
issn = "1570-9639",
publisher = "Elsevier",
number = "11",
}