Cytotoxicity and in Vitro Degradation Kinetics of Foundry-Compatible Semiconductor Nanomembranes and Electronic Microcomponents

Jan Kai Chang, M. A.Bashar Emon, Chia Shuo Li, Quansan Yang, Hui Ping Chang, Zijian Yang, Chih I. Wu, M. Taher Saif, John A. Rogers

Research output: Contribution to journalArticle

Abstract

Foundry-compatible materials and processing approaches serve as the foundations for advanced, active implantable microsystems that can dissolve in biofluids into biocompatible reaction products, with broad potential applications in biomedicine. The results reported here include in vitro studies of the dissolution kinetics and nanoscale bioresorption behaviors of device-grade thin films of Si, SiNx, SiO2, and W in the presence of dynamic cell cultures via atomic force microscopy and X-ray photoemission spectroscopy. In situ investigations of cell-extracellular mechanotransduction induced by cellular traction provide insights into the cytotoxicity of these same materials and of microcomponents formed with them using foundry-compatible processes, indicating potential cytotoxicity elicited by W at concentrations greater than 6 mM. The findings are of central relevance to the biocompatibility of modern Si-based electronics technologies as active, bioresorbable microsystems that interface with living tissues.

Original languageEnglish (US)
JournalACS Nano
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • bioresorption
  • cell metabolism
  • cell traction force
  • implantable electronics
  • toxicity

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Cytotoxicity and in Vitro Degradation Kinetics of Foundry-Compatible Semiconductor Nanomembranes and Electronic Microcomponents'. Together they form a unique fingerprint.

  • Cite this

    Chang, J. K., Emon, M. A. B., Li, C. S., Yang, Q., Chang, H. P., Yang, Z., Wu, C. I., Saif, M. T., & Rogers, J. A. (Accepted/In press). Cytotoxicity and in Vitro Degradation Kinetics of Foundry-Compatible Semiconductor Nanomembranes and Electronic Microcomponents. ACS Nano. https://doi.org/10.1021/acsnano.8b04513