Cytoskeleton dynamics: Fluctuations within the network

Predrag Bursac, Ben Fabry, Xavier Trepat, Guillaume Lenormand, James P. Butler, Ning Wang, Jeffrey J. Fredberg, Steven S. An

Research output: Contribution to journalArticlepeer-review


Out-of-equilibrium systems, such as the dynamics of a living cytoskeleton (CSK), are inherently noisy with fluctuations arising from the stochastic nature of the underlying biochemical and molecular events. Recently, such fluctuations within the cell were characterized by observing spontaneous nano-scale motions of an RGD-coated microbead bound to the cell surface [Bursac et al., Nat. Mater. 4 (2005) 557-561]. While these reported anomalous bead motions represent a molecular level reorganization (remodeling) of microstructures in contact with the bead, a precise nature of these cytoskeletal constituents and forces that drive their remodeling dynamics are largely unclear. Here, we focused upon spontaneous motions of an RGD-coated bead and, in particular, assessed to what extent these motions are attributable to (i) bulk cell movement (cell crawling), (ii) dynamics of focal adhesions, (iii) dynamics of lipid membrane, and/or (iv) dynamics of the underlying actin CSK driven by myosin motors.

Original languageEnglish (US)
Pages (from-to)324-330
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Apr 6 2007
Externally publishedYes


  • Airway smooth muscle
  • Cytoskeleton
  • Lipid dynamics
  • Remodeling

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology


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