TY - JOUR
T1 - Cytokine-induced sickness behavior
AU - Kelley, Keith W.
AU - Bluthé, Rose Marie
AU - Dantzer, Robert
AU - Zhou, Jian Hua
AU - Shen, Wen Hong
AU - Johnson, Rodney W.
AU - Broussard, Suzanne R.
N1 - Funding Information:
This research was supported by Grants to K.W.K. (MH-51569 and AI-50442) and R.W.J. (AG-16710) from the National Institutes of Health.
PY - 2003/2
Y1 - 2003/2
N2 - The behavioral repertoire of humans and animals changes dramatically following infection. Sick individuals have little motivation to eat, are listless, complain of fatigue and malaise, loose interest in social activities and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain and fail to concentrate. Proinflammatory cytokines acting in the brain cause sickness behaviors. These nearly universal behavioral changes are a manifestation of a central motivational state that is designed to promote recovery. Exaggerated symptoms of sickness in cancer patients, such as cachexia, can be life-threatening. However, quality of life is often drastically impaired before the cancer becomes totally debilitating. Although basic studies in psychoneuroimmunology have defined proinflammatory cytokines as the central mediators of sickness behavior, a much better understanding of how cytokine and neurotransmitter receptors communicate with each other is needed. Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients.
AB - The behavioral repertoire of humans and animals changes dramatically following infection. Sick individuals have little motivation to eat, are listless, complain of fatigue and malaise, loose interest in social activities and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain and fail to concentrate. Proinflammatory cytokines acting in the brain cause sickness behaviors. These nearly universal behavioral changes are a manifestation of a central motivational state that is designed to promote recovery. Exaggerated symptoms of sickness in cancer patients, such as cachexia, can be life-threatening. However, quality of life is often drastically impaired before the cancer becomes totally debilitating. Although basic studies in psychoneuroimmunology have defined proinflammatory cytokines as the central mediators of sickness behavior, a much better understanding of how cytokine and neurotransmitter receptors communicate with each other is needed. Advances that have been made during the past decade should now be extended to clinical studies in an attempt to alleviate sickness symptoms and improve quality of life for cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=0037293972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037293972&partnerID=8YFLogxK
U2 - 10.1016/S0889-1591(02)00077-6
DO - 10.1016/S0889-1591(02)00077-6
M3 - Article
C2 - 12615196
AN - SCOPUS:0037293972
SN - 0889-1591
VL - 17
SP - 112
EP - 118
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
IS - 1 SUPPL.
ER -