The characterization of multiple new P450s reported at this meeting extended the major theme of the First International Workshop. It is clear that the study of this complex family of enzymes may provide insight into a variety of fields. Understanding of the regulation of these genes is at an early stage, and it is likely that cis-acting and trans-acting regulatory elements will be defined in the next few years. Expression of the mammalian proteins in microbial organisms will likely lead to new understanding of the enzymatic mechanisms of these enzymes, both through physicochemical analysis and in vitro mutagenic studies. How this complex group of enzymes with multiple substrate specificities and many different physiological regulators could have evolved from a presumed single gene remains a fascinating question.
ASJC Scopus subject areas
- Molecular Biology