Cu-Catalyzed Three-Component Carboamination of Alkenes

Samuel N. Gockel, Travis L. Buchanan, Kami L. Hull

Research output: Contribution to journalArticlepeer-review

Abstract

Copper-catalyzed intermolecular carboamination of alkenes with α-halocarbonyls and amines is presented with 42 examples. Electron rich, electron poor, and internal styrenes, as well as α-olefins, are functionalized with α-halocarbonyls and aryl or aliphatic amines. Mechanistic investigations suggest the reaction is proceeding through addition of a carbon-centered radical across an olefin followed by oxidation to form a 5-membered oxocarbenium intermediate and subsequent nucleophilic ring opening to forge the C-N bond.

Original languageEnglish (US)
Pages (from-to)58-61
Number of pages4
JournalJournal of the American Chemical Society
Volume140
Issue number1
DOIs
StatePublished - Jan 10 2018

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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