Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450

Ilme Schlichting, Joel Berendzen, Kelvia Glu, Ann M. Robert, Dagmar Ring, Gregory A. Petsko, Matthew Davies, Ernest J. Muller, David Benson, Steven Sligar

Research output: Contribution to journalArticlepeer-review

Abstract

P450 of many structure of difierrut 150 riiniplxc-s havr been ihMerinincd. the structure ul ihe hiorheui'n import;nii 15U.cain])hor.()-j coni])iex lias not tieen solved, yet. as it i- unstable due to ;int(niidation. Tliis rc(iuires io collée I ! he diffract ion data oft he hurt-lived nniple.x oilhei fast or to prolong its lifi1 linir. Vr rho-e t he latter by u,ins; (TvorrysiMlography to dclenniuc1 the st ni<%t uro-; of unt able in! ennrdiates Ofenring aloii'j; l he react ton pat hw(iv of p 1) ferroupi.)ii.caiii])lior, oi : he lemaiy p 150.< aiii|)lior.Oj (oinplex and of a complex that ve identii a:- an <Ayfeirl species, ['he methods uxcd. and I he M n M! ures obtained will be di.-.eiisMd.

Original languageEnglish (US)
Pages (from-to)A769
JournalFASEB Journal
Volume11
Issue number9
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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