Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450

Ilme Schlichting; Joel Berendzen; Kelvia Glu; Ann M. Robert; Dagmar Ring; Gregory A. Petsko; Matthew Davies; Ernest J. Muller; David Benson; Steven Sligar

Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450

Ilme Schlichting, Joel Berendzen, Kelvia Glu, Ann M. Robert, Dagmar Ring, Gregory A. Petsko, Matthew Davies, Ernest J. Muller, David Benson, Steven Sligar

Biochemistry

Research output: Contribution to journal › Article › peer-review

Abstract

P450 of many structure of difierrut 150 riiniplxc-s havr been ihMerinincd. the structure ul ihe hiorheui'n import;nii 15U.cain])hor.()-j coni])iex lias not tieen solved, yet. as it i- unstable due to ;int(niidation. Tliis rc(iuires io collée I ! he diffract ion data oft he hurt-lived nniple.x oilhei fast or to prolong its lifi1 linir. Vr rho-e t he latter by u,ins; (TvorrysiMlography to dclenniuc1 the st ni<%t uro-; of unt able in! ennrdiates Ofenring aloii'j; l he react ton pat hw(iv of p 1) ferroupi.)ii.caiii])lior, oi : he lemaiy p 150.< aiii|)lior.Oj (oinplex and of a complex that ve identii a:- an <Ayfeirl species, ['he methods uxcd. and I he M n M! ures obtained will be di.-.eiisMd.

Original language	English (US)
Pages (from-to)	A769
Journal	FASEB Journal
Volume	11
Issue number	9
State	Published - 1997

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

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title = "Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450",

abstract = "P450 of many structure of difierrut 150 riiniplxc-s havr been ihMerinincd. the structure ul ihe hiorheui'n import;nii 15U.cain])hor.()-j coni])iex lias not tieen solved, yet. as it i- unstable due to ;int(niidation. Tliis rc(iuires io coll{\'e}e I ! he diffract ion data oft he hurt-lived nniple.x oilhei fast or to prolong its lifi1 linir. Vr rho-e t he latter by u,ins; (TvorrysiMlography to dclenniuc1 the st ni<%t uro-; of unt able in! ennrdiates Ofenring aloii'j; l he react ton pat hw(iv of p 1) ferroupi.)ii.caiii])lior, oi : he lemaiy p 150.< aiii|)lior.Oj (oinplex and of a complex that ve identii a:- an <Ayfeirl species, ['he methods uxcd. and I he M n M! ures obtained will be di.-.eiisMd.",

author = "Ilme Schlichting and Joel Berendzen and Kelvia Glu and Robert, {Ann M.} and Dagmar Ring and Petsko, {Gregory A.} and Matthew Davies and Muller, {Ernest J.} and David Benson and Steven Sligar",

year = "1997",

language = "English (US)",

volume = "11",

pages = "A769",

journal = "FASEB Journal",

issn = "0892-6638",

publisher = "FASEB",

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TY - JOUR

T1 - Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450

AU - Schlichting, Ilme

AU - Berendzen, Joel

AU - Glu, Kelvia

AU - Robert, Ann M.

AU - Ring, Dagmar

AU - Petsko, Gregory A.

AU - Davies, Matthew

AU - Muller, Ernest J.

AU - Benson, David

AU - Sligar, Steven

PY - 1997

Y1 - 1997

N2 - P450 of many structure of difierrut 150 riiniplxc-s havr been ihMerinincd. the structure ul ihe hiorheui'n import;nii 15U.cain])hor.()-j coni])iex lias not tieen solved, yet. as it i- unstable due to ;int(niidation. Tliis rc(iuires io collée I ! he diffract ion data oft he hurt-lived nniple.x oilhei fast or to prolong its lifi1 linir. Vr rho-e t he latter by u,ins; (TvorrysiMlography to dclenniuc1 the st ni<%t uro-; of unt able in! ennrdiates Ofenring aloii'j; l he react ton pat hw(iv of p 1) ferroupi.)ii.caiii])lior, oi : he lemaiy p 150.< aiii|)lior.Oj (oinplex and of a complex that ve identii a:- an <Ayfeirl species, ['he methods uxcd. and I he M n M! ures obtained will be di.-.eiisMd.

AB - P450 of many structure of difierrut 150 riiniplxc-s havr been ihMerinincd. the structure ul ihe hiorheui'n import;nii 15U.cain])hor.()-j coni])iex lias not tieen solved, yet. as it i- unstable due to ;int(niidation. Tliis rc(iuires io collée I ! he diffract ion data oft he hurt-lived nniple.x oilhei fast or to prolong its lifi1 linir. Vr rho-e t he latter by u,ins; (TvorrysiMlography to dclenniuc1 the st ni<%t uro-; of unt able in! ennrdiates Ofenring aloii'j; l he react ton pat hw(iv of p 1) ferroupi.)ii.caiii])lior, oi : he lemaiy p 150.< aiii|)lior.Oj (oinplex and of a complex that ve identii a:- an <Ayfeirl species, ['he methods uxcd. and I he M n M! ures obtained will be di.-.eiisMd.

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AN - SCOPUS:0007308033

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Crystal structures of intermediates occuring along the reaction pathway of cytochrome P450

Abstract

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