Crystal structure of doisynolic acid and the structure of other products formed during its synthesis

Dae Yoon Chi, Scott R. Wilson, John A. Katzenellenbogen

Research output: Contribution to journalArticlepeer-review

Abstract

The crystal structure of the D-seco-estrogen doisynolic acid shows it to have the natural S configuration at the position derived from C-14 in estrone. Two major by-products during the synthesis of doisynolic acid from estrone are shown to be dimeric steroids. One is an aldol condensation product, and the other appears to arise from an alkaline cleavage of the aldol product.

Original languageEnglish (US)
Pages (from-to)261-264
Number of pages4
JournalSteroids
Volume60
Issue number3
DOIs
StatePublished - Mar 1995

Keywords

  • doisynolic acid
  • estrogens
  • stereochemistry
  • X-ray crystallography

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry

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