CryoEM-based hybrid modeling approaches for structure determination

C. Keith Cassidy, Benjamin A. Himes, Zaida Luthey-Schulten, Peijun Zhang

Research output: Contribution to journalReview articlepeer-review


Recent advances in cryo-electron microscopy (cryoEM) have dramatically improved the resolutions at which vitrified biological specimens can be studied, revealing new structural and mechanistic insights over a broad range of spatial scales. Bolstered by these advances, much effort has been directed toward the development of hybrid modeling methodologies for the construction and refinement of high-fidelity atomistic models from cryoEM data. In this brief review, we will survey the key elements of cryoEM-based hybrid modeling, providing an overview of available computational tools and strategies as well as several recent applications.

Original languageEnglish (US)
Pages (from-to)14-23
Number of pages10
JournalCurrent Opinion in Microbiology
StatePublished - Jun 2018

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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