@article{733f0a97467443dcb2d1ada1c507f147,
title = "Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections",
abstract = "The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack of knowledge about the antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and from infected or immunized mice. Our results show that, although cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of a non-neutralizing antibody response to conserved epitopes in the spike. Whether such low or non-neutralizing antibody response leads to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding antigenicity differences between SARS-CoV-2 and SARS-CoV but also has implications for immunogen design and vaccine development.",
author = "Huibin Lv and Wu, {Nicholas C.} and Tsang, {Owen Tak Yin} and Meng Yuan and Perera, {Ranawaka A.P.M.} and Leung, {Wai Shing} and So, {Ray T.Y.} and Chan, {Jacky Man Chun} and Yip, {Garrick K.} and Chik, {Thomas Shiu Hong} and Yiquan Wang and Choi, {Chris Yau Chung} and Yihan Lin and Ng, {Wilson W.} and Jincun Zhao and Poon, {Leo L.M.} and Peiris, {J. S.Malik} and Wilson, {Ian A.} and Mok, {Chris K.P.}",
note = "Funding Information: This work was supported by Calmette and Yersin scholarship from the Pasteur International Network Association (H.L.), NIH K99 AI139445 (N.C.W.), Bill and Melinda Gates Foundation OPP1170236 (I.A.W.), Guangzhou Medical University High-level University Innovation Team Training Program (Guangzhou Medical University released [2017] No. 159 ) (C.K.P.M. and J.S.M.P.), the US National Institutes of Health (contract no. HHSN272201400006C ) (J.S.M.P.), National Natural Science Foundation of China ( NSFC )/Research Grants Council ( RGC ) Joint Research Scheme ( N_HKU737/18 ) (C.K.P.M. and J.S.M.P.), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. T11-712/19-N ) (J.S.M.P.), and the International Cooperation and Exchange of the National Natural Science Foundation of China (grant 8181101118 ) (J.Z.). We acknowledge the support of the clinicians who facilitated this study, including Drs. John Yu Hong Chan, Daphne Pui-Lin Lau, and Ying Man Ho, and the dedicated clinical team at the Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, and the patients who kindly consented to participate in this investigation. Funding Information: This work was supported by Calmette and Yersin scholarship from the Pasteur International Network Association (H.L.), NIH K99 AI139445 (N.C.W.), Bill and Melinda Gates Foundation OPP1170236 (I.A.W.), Guangzhou Medical University High-level University Innovation Team Training Program (Guangzhou Medical University released [2017] No. 159) (C.K.P.M. and J.S.M.P.), the US National Institutes of Health (contract no. HHSN272201400006C) (J.S.M.P.), National Natural Science Foundation of China (NSFC)/Research Grants Council (RGC) Joint Research Scheme (N_HKU737/18) (C.K.P.M. and J.S.M.P.), the Research Grants Council of the Hong Kong Special Administrative Region, China (Project no. T11-712/19-N) (J.S.M.P.), and the International Cooperation and Exchange of the National Natural Science Foundation of China (grant 8181101118) (J.Z.). We acknowledge the support of the clinicians who facilitated this study, including Drs. John Yu Hong Chan, Daphne Pui-Lin Lau, and Ying Man Ho, and the dedicated clinical team at the Infectious Diseases Centre, Princess Margaret Hospital, Hospital Authority of Hong Kong, and the patients who kindly consented to participate in this investigation. H.L. N.C.W. O.T.-Y.T. J.S.M.P. I.A.W. and C.K.P.M. conceived and designed the study. N.C.W. and M.Y. expressed and purified the proteins. H.L. R.T.Y.S. W.W.N. G.K.Y. Y.L. Y.W. and R.A.P.M.P. performed the experiments. O.T.-Y.T. W.S.L. J.M.C.C. T.S.H.C. and C.Y.C.C. organized patient recruitment, data collection, and sampling. H.L. N.C.W. J.Z. L.L.M.P. and C.K.P.M. analyzed the data. H.L. N.C.W. J.S.M.P. I.A.W. and C.K.P.M. wrote the paper, and all authors reviewed and edited the paper. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jun,
day = "2",
doi = "10.1016/j.celrep.2020.107725",
language = "English (US)",
volume = "31",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}