Cross-optical-beam nonlinear photoacoustic microscopy

Liren Zhu, Liang Gao, Lei Li, Lidai Wang, Teng Ma, Qifa Zhou, K. Kirk Shung, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We present a photoacoustic microscopy (PAM) technique with an optical sectioning capability. By combining crossoptical- beam illumination with nonlinear PAM, an axial resolution of 8.7 μm was measured, demonstrating a fourfold improvement over the acoustically determined value. Compared to methods relying on high-frequency ultrasound transducers to improve the axial resolution, our approach offers a greater working distance and a higher signal-to-noise ratio.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2014
ISBN (Print)9780819498564
StatePublished - 2014
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2014 - San Francisco, CA, United States
Duration: Feb 2 2014Feb 5 2014

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotons Plus Ultrasound: Imaging and Sensing 2014
Country/TerritoryUnited States
CitySan Francisco, CA


  • Axial resolution
  • Cross-beam illumination
  • Nonlinear optics
  • Optical sectioning
  • Photoacoustic microscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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