Cross-linked dendrimer hosts containing reporter groups for amine guests

Eric Mertz, Steven C Zimmerman

Research output: Contribution to journalArticle

Abstract

The integration of a chromogenic reporter group into the recently reported (Zimmerman, S. C.; Wendland, M. S.; Rakow, N. A.; Zharov, I.; Suslick, K. S. Nature 2002, 418, 399-403) monomolecular imprinting approach is described. The resulting highly cross-linked, macromolecular hosts show rapid, selective, high affinity, two-point binding of straight-chain diamine guests. Over longer times, the hosts are more promiscuous, binding a broader range of diamines. A rigorous test of imprinting was performed wherein the cross-reactivities of two dendrimers derived from different templates are compared. The test reveals a guest-dependent kinetic binding effect masquerading as evidence of a highly selective two-point imprinting process.

Original languageEnglish (US)
Pages (from-to)3424-3425
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number12
DOIs
StatePublished - Mar 26 2003

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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