Cross-coupling reactions of organosilicon compounds: New concepts and recent advances

Scott Eric Denmark, Ramzi Farah Sweis

Research output: Contribution to journalReview articlepeer-review


This review highlights the rapid evolution of the newly-developed class of palladium-catalyzed cross-coupling reactions of organosilicon compounds. A myriad of heteroatom-containing silicon moieties (silyl hydrides, siletanes, silanols, silyl ethers, orthosiliconates, di- and polysiloxanes and pyridylsilanes) undergo mild and stereospecific cross-coupling. The diversity of methods for introduction of silicon groups into organic molecules and the range of organic electrophiles that can be used are emphasized.

Original languageEnglish (US)
Pages (from-to)1531-1541
Number of pages11
JournalChemical and Pharmaceutical Bulletin
Issue number12
StatePublished - Dec 2002


  • Cross-coupling
  • Organosilicon
  • Palladium

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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