Cross-coupling reactions of arylsilanols with substituted aryl halides

Scott E. Denmark, Michael H. Ober

Research output: Contribution to journalArticlepeer-review


(Matrix presented) The palladium-catalyzed cross-coupling of arylsilanols with aryl iodides and aryl bromides (in the presence of cesium carbonate) furnished various biaryl products in high yield. An extensive series of optimizations led to the identification of key variables, including activator, solvent, catalyst, and hydration level, that influence the rate and selectivity of the process. Manipulation of these features provided an effective coupling method of wide scope and generality.

Original languageEnglish (US)
Pages (from-to)1357-1360
Number of pages4
JournalOrganic Letters
Issue number8
StatePublished - Apr 17 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of 'Cross-coupling reactions of arylsilanols with substituted aryl halides'. Together they form a unique fingerprint.

Cite this