Abstract
Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, and its mechanism of action and scope of activity are unknown. Here we show that cribrostatin 6 has broad anticancer activity, potently inducing apoptotic cell death that is not preceded by any defined cell cycle arrest. Consistent with this data, we find that cribrostatin 6 treated cells have large amounts of reactive oxygen species (ROS) and, based on transcript profiling experiments and other data, this ROS generation is likely the primary mechanism by which cribrostatin 6 induces apoptosis. Given the success of certain ROS producers as anticancer agents, cribrostatin 6 has potential as a novel chemotherapeutic agent.
Original language | English (US) |
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Pages (from-to) | 562-573 |
Number of pages | 12 |
Journal | Investigational New Drugs |
Volume | 29 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2011 |
Keywords
- Apoptosis
- Cancer stem cells
- Cribrostatin 6
- Drug-resistant cell lines
- HMOX1
- Quiescent 3T3
- Quiescent cells
- Quinone
- ROS
- Transcript profile
ASJC Scopus subject areas
- Oncology
- Pharmacology
- Pharmacology (medical)