TY - JOUR
T1 - Creatine Monohydrate Supplementation, but not Creatyl-L-Leucine, Increased Muscle Creatine Content in Healthy Young Adults
T2 - A Double-Blind Randomized Controlled Trial
AU - Askow, Andrew T.
AU - Paulussen, Kevin J.M.
AU - McKenna, Colleen F.
AU - Salvador, Amadeo F.
AU - Scaroni, Susannah E.
AU - Hamann, Jade S.
AU - Ulanov, Alexander V.
AU - Li, Zhong
AU - Paluska, Scott A.
AU - Beaudry, Kayleigh M.
AU - De Lisio, Michael
AU - Burd, Nicholas A.
N1 - Publisher Copyright:
© 2022 Human Kinetics, Inc.
PY - 2022/11
Y1 - 2022/11
N2 - Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.
AB - Creatine (Cr) supplementation is a well-established strategy to enhance gains in strength, lean body mass, and power from a period of resistance training. However, the effectiveness of creatyl-L-leucine (CLL), a purported Cr amide, is unknown. Therefore, the purpose of this study was to assess the effects of CLL on muscle Cr content. Twenty-nine healthy men (n = 17) and women (n = 12) consumed 5 g/day of either Cr monohydrate (n = 8; 28.5 ± 7.3 years, 172.1 ± 11.0 cm, 76.6 ± 10.7 kg), CLL (n = 11; 29.2 ± 9.3 years, 170.3 ± 10.5 cm, 71.9 ± 14.5 kg), or placebo (n = 10; 30.3 ± 6.9 years, 167.8 ± 9.9 cm, 69.9 ± 11.1 kg) for 14 days in a randomized, double-blind design. Participants completed three bouts of supervised resistance exercise per week. Muscle biopsies were collected before and after the intervention for quantification of muscle Cr. Cr monohydrate supplementation which significantly increased muscle Cr content with 14 days of supplementation. No changes in muscle Cr were observed for the placebo or CLL groups. Cr monohydrate supplementation is an effective strategy to augment muscle Cr content while CLL is not.
KW - anabolism
KW - dietary supplements
KW - muscle hypertrophy
KW - nutritional supplements
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U2 - 10.1123/ijsnem.2022-0074
DO - 10.1123/ijsnem.2022-0074
M3 - Article
C2 - 36007881
AN - SCOPUS:85140416243
SN - 1526-484X
VL - 32
SP - 446
EP - 452
JO - International journal of sport nutrition and exercise metabolism
JF - International journal of sport nutrition and exercise metabolism
IS - 6
ER -